치수 및 치근단병소에서 Prostaglandin E₂, 6-keto-Prostaglandin F₁α, Leukotriene B₄의 분포에 관한 연구
THE CONCENTRATIONS OF PROSTAGLANDIN E₂, 6-KETO-PROSTAGLANDIN F₁α, AND LEUKOTRIENE B₄IN PULPAL AND PERIAPICAL LESIONS
손원준, 백승호, 안석준,
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손원준 ( ) - 서울대학교 치과대학 치과보존학교실
백승호 ( ) - 서울대학교 치과대학 치과보존학교실
안석준 ( ) - 서울대학교 치과대학 치과보존학교실
KMID : 0362320000250020193
Abstract
Prostaglandins (PGs) and Leukotrienes (LTs) have been implicated in the genesis of pulpal and periapical inflammation. In this study, the relationships among PGE₂, 6-keto-PG F₁, α (a stable metabolite of PGI₂) and LTB4 concentrations in inflamed pulp and periapical lesions were discussed. Pulp tissue were obtained in routine endodontic treatment and periapical lesions in periapical surgery after clinical diagnoses were made. These specimens were divided into four groups as normal pulp group(Control group), acute pulpitis group, chronic pulpitis group, and periapical lesion group. Pulp tissue and periapical lesions were stored in liquid nitrogen. The concentration of PGE₂. PGI₂ and LTB₄were measured with ELISA. The data were analyzed by one-way ANOVA.
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Significantly higher levels of PGE₂, 6-keto-PG F₁α and LTB₄were found in acute pulpitis group than chronic pulpitis group and periapical lesion giroup(p<0.05). Periapical lesion group showed significantly higher mean concentrations of PGE₂and LTB₄than chronic pulpitis group. In control and chronic pulpitisgroup, significant higher levels of PGI₂than PGE₂and LTB₄were found. These results suggested that the high, levels of PGE₂and LTB₄in periapical lesions may be due to rich endothelium., fibroblast and lymph0 cyte known as the main producers of PGE₂and LTB₄. PGI₂may be thought to one of the most abundant PGs in normal pulp tissue.
Pulp;Periapical lesion;Prostaglandin E₂;6-keto-prostaglandin F₁α, Leukotriene B₄;Enzymeimmunoassay;Immunohistochemical staining
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